Early Awaking

Anxiety
Depression
Sleep
Stress

Sleep

Early Awaking

Early awakening is a form of recurrent sleep disorder and can cause exhaustion. This problem is commonly associated with anxiety and can impair performance the next day, especially in tasks that require focus and attention such as work and physical activities.

Table of relations

Dietary supplement

Consistent effects

Strength of effects

Scientific articles

Published articles about Ashwagandha and Early Awaking

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study

Study link https://pubmed.ncbi.nlm.nih.gov/31728244/

Health Goal Sleep, Anxiety, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study

Study link https://pubmed.ncbi.nlm.nih.gov/32021735/

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients

Study link https://pubmed.ncbi.nlm.nih.gov/23142798/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Controlled Clinical Trial

A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY OF ASHWAGANDHA ON GENERALIZED ANXIETY DISORDER

Study link http://www.iamj.in/posts/images/upload/01.05.14_IAMJ.pdf

Health Goal Sleep, Anxiety, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study

Study link https://www.semanticscholar.org/paper/A-Standardized-Withania-Somnifera-Extract-Reduces-A-Auddy-Hazra/46bdaebfcf4f00730ad217fd6bb88228964e4c2e

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study

Study link https://pubmed.ncbi.nlm.nih.gov/32818573/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults

Study link https://pubmed.ncbi.nlm.nih.gov/32540634/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Ashwagandha

Study Level Randomized, Double Blind, Controlled Clinical Trial

Ashwagandha

See All 7 studies

Published articles about Chamomile and Early Awaking

Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study

Study link https://pubmed.ncbi.nlm.nih.gov/21939549/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Chamomile

Study Level Randomized, Controlled Clinical Trial

Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial

Study link https://pubmed.ncbi.nlm.nih.gov/26483209/

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Chamomile

Study Level Randomized, Double Blind, Controlled Clinical Trial

Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial

Study link https://pubmed.ncbi.nlm.nih.gov/28616420/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Chamomile

Study Level Randomized, Controlled Clinical Trial

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study

Study link https://pubmed.ncbi.nlm.nih.gov/31714321/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Chamomile

Study Level Randomized, Double Blind, Controlled Clinical Trial

A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality

Study link https://pubmed.ncbi.nlm.nih.gov/21294203/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Chamomile

Study Level Randomized, Double Blind, Controlled Clinical Trial

Chamomile

See All 5 studies

Published articles about Lemon Balm and Early Awaking

Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances

Study link https://pubmed.ncbi.nlm.nih.gov/22207903/

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency

Dietary Supplement Lemon Balm

Study Level Clinical Trial

The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina

Study link https://pubmed.ncbi.nlm.nih.gov/29908682/

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency

Dietary Supplement Lemon Balm

Study Level Randomized, Controlled Clinical Trial

Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties

Study link https://pubmed.ncbi.nlm.nih.gov/12888775/

Health Goal Sleep, Anxiety, Stress, Early Awaking, Sleep Latency

Dietary Supplement Lemon Balm

Study Level Randomized, Double Blind, Controlled Clinical Trial

Lemon Balm

See All 3 studies

Published articles about Melatonin and Early Awaking

Prolonged-release Melatonin Improves Sleep Quality And Morning Alertness In Insomnia Patients Aged 55 Years And Older And Has No Withdrawal Effects

Study link https://pubmed.ncbi.nlm.nih.gov/18036082/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Randomized, Controlled Clinical Trial

Evaluation Of Sleep, Puberty And Mental Health In Children With Long-term Melatonin Treatment For Chronic Idiopathic Childhood Sleep Onset Insomnia

Study link https://pubmed.ncbi.nlm.nih.gov/21340475/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Clinical Trial

The Effect Of Prolonged-release Melatonin On Sleep Measures And Psychomotor Performance In Elderly Patients With Insomnia

Study link https://pubmed.ncbi.nlm.nih.gov/19584739/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Randomized, Double Blind, Controlled Clinical Trial

Prophylaxis Of Migraine With Melatonin: A Randomized Controlled Trial

Study link https://pubmed.ncbi.nlm.nih.gov/20975054/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Randomized, Controlled Clinical Trial

The Effects Of Melatonin On Tinnitus And Sleep

Study link https://pubmed.ncbi.nlm.nih.gov/16455366/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Clinical Trial

Melatonin: can it stop the ringing?

Study link https://pubmed.ncbi.nlm.nih.gov/21859051/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Randomized, Controlled Clinical Trial

Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial

Study link https://pubmed.ncbi.nlm.nih.gov/23602498/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Randomized, Double Blind, Controlled Clinical Trial

Scientific Opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Study link https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2011.2241

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level EFSA's Scientific Opinion

Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis

Study link https://pubmed.ncbi.nlm.nih.gov/29908879/#affiliation-1

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Meta-analysis

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders

Study link https://pubmed.ncbi.nlm.nih.gov/28648359/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Review

Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials

Study link https://pubmed.ncbi.nlm.nih.gov/31982807/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Melatonin

Study Level Meta-analysis

Melatonin

See All 11 studies

Published articles about Omega 3 and Early Awaking

Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders – Results from a double-blind, randomized and placebo-controlled clinical trial

Study link https://pubmed.ncbi.nlm.nih.gov/30317101/

Health Goal Sleep, Anxiety, Depression, Early Awaking, Sleep Latency

Dietary Supplement Omega 3

Study Level Randomized, Double Blind, Controlled Clinical Trial

The effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trial

Study link https://pubmed.ncbi.nlm.nih.gov/28707491/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Omega 3

Study Level Randomized, Controlled Clinical Trial

Omega-3 long-chain polyunsaturated fatty acid and sleep: a systematic review and meta-analysis of randomized controlled trials and longitudinal studies

Study link https://pubmed.ncbi.nlm.nih.gov/33382879/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Omega 3

Study Level Meta-analysis

Sleep Apnea and Inflammation – Getting a Good Night’s Sleep with Omega-3 Supplementation

Study link https://pubmed.ncbi.nlm.nih.gov/24348457/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Omega 3

Study Level Review

Omega 3

See All 4 studies

Published articles about PEA and Early Awaking

Endocannabinoids and sleep

Study link https://pubmed.ncbi.nlm.nih.gov/27756691/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement PEA

Study Level Review

Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study

Study link https://pubmed.ncbi.nlm.nih.gov/34522787/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement PEA

Study Level Randomized, Double Blind, Controlled Clinical Trial

Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled Study

Study link https://pubmed.ncbi.nlm.nih.gov/29676237/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement PEA

Study Level Clinical Trial

Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide)

Study link https://pubmed.ncbi.nlm.nih.gov/31610409/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement PEA

Study Level Clinical Trial

PEA

See All 4 studies

Published articles about Rhodiola Rosea and Early Awaking

Rhodiola rosea (SHR-5), Part 2: A standardized extract of Rhodiola rosea is shown to be effective in the treatment of mild to moderate depression

Study link https://pubmed.ncbi.nlm.nih.gov/24722617/

Health Goal Sleep, Depression, Early Awaking, Sleep Latency

Dietary Supplement Rhodiola Rosea

Study Level Randomized, Controlled Clinical Trial

The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms

Study link https://pubmed.ncbi.nlm.nih.gov/26502953/

Health Goal Sleep, Anxiety, Stress, Depression, Early Awaking, Sleep Latency

Dietary Supplement Rhodiola Rosea

Study Level Randomized, Controlled Clinical Trial

Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies

Study link https://pubmed.ncbi.nlm.nih.gov/17901042/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Rhodiola Rosea

Study Level Clinical Trial

Rhodiola Rosea

See All 3 studies

Published articles about Saffron and Early Awaking

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial

Study link https://pubmed.ncbi.nlm.nih.gov/32056539/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials

Study link https://pubmed.ncbi.nlm.nih.gov/31987241/

Health Goal Sleep, Anxiety, Depression, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Meta-analysis

Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental study

Study link https://www.ajol.info/index.php/tjpr/article/view/164280

Health Goal Sleep, Anxiety, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Clinical Trial

The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial

Study link https://pubmed.ncbi.nlm.nih.gov/30477839/

Health Goal Sleep, Anxiety, Depression, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

The effect of saffron ( Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial

Study link https://pubmed.ncbi.nlm.nih.gov/29531568/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study

Study link https://pubmed.ncbi.nlm.nih.gov/30477864/#affiliation-1

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

Effects of saffron supplementation on improving sleep quality: a meta-analysis of randomized controlled trials

Study link https://pubmed.ncbi.nlm.nih.gov/35325766/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Meta-analysis

Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial

Study link https://pubmed.ncbi.nlm.nih.gov/33925432/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study

Study link https://pubmed.ncbi.nlm.nih.gov/34438361/

Health Goal Sleep, Early Awaking, Sleep Latency, Sleep Duration

Dietary Supplement Saffron

Study Level Randomized, Double Blind, Controlled Clinical Trial

Saffron

See All 9 studies

Published articles about Theanine and Early Awaking

The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial

Study link https://pubmed.ncbi.nlm.nih.gov/22214254/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Randomized, Double Blind, Controlled Clinical Trial

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

Study link https://pubmed.ncbi.nlm.nih.gov/31623400/

Health Goal Sleep, Anxiety, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Randomized, Controlled Clinical Trial

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study

Study link https://pubmed.ncbi.nlm.nih.gov/27396868/

Health Goal Sleep, Anxiety, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Clinical Trial

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial

Study link https://pubmed.ncbi.nlm.nih.gov/30580081/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Clinical Trial

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep

Study link https://pubmed.ncbi.nlm.nih.gov/30707852/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Clinical Trial

Effect of L-theanine on glutamatergic function in patients with schizophrenia

Study link https://pubmed.ncbi.nlm.nih.gov/25896423/

Health Goal Sleep, Early Awaking, Sleep Latency

Dietary Supplement Theanine

Study Level Clinical Trial

Theanine

See All 6 studies

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